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My initial challenge in medicine was to help HIV patients survive before we had any antiviral medications. I report that we not only made them live beyond the HIV death sentence, in all cases we converted patients into champion athletes. From this we learned a great deal of science that enhances quality of life and extends life. Early on in desperation we set up double-blind studies (whereby neither the physician nor patient knows if they are actually getting the treatment drug/nutrient). We tested absolutely every single nutrient and drug that had any positive claim: from lemon leaf with olive oil to homeopathy! In the end, we learned WHAT REALLY WORKS and what did not! One of the most amazing discoveries was the value of Glutamine – Which is part of a general detoxification reaction studied in human biochemistry. The results were so astonishing the local hospitals created liver detox clinics that used nothing more than glutamine and alpha lipoic acid. Glutamine is the major constituent of the immune system; main biochemical of the GI tract; a main biochemical constituent for the building, break-down & modification of amino acids (proteins or the building blocks of the body); is the only chemical that can detox your body of nitrogen, ammonia & Uric acid compounds, and thus used to cleanse the liver & kidneys. It is also used as biochemical in brain. That’s a hellavua lot! In addition to detoxifying your body of ammonia & balancing pH, the liver & kidneys must dispose of an enormous array of pharmaceutical and environmental chemicals. Of the numerous remedies, medicinal agents, chemicals, and herbal remedies in existence, more than 600 are recognized as being capable of bringing grave harm to the liver and kidneys. HIV patients often presented with a co-infection of hepatotoxic Hepatitis C. Hepatitis along with an astonishing pharmacological regimen, (often 40 to 60 pills a day), presented us with a real challenge. The solution, Glutamine, alpha-lipoic acid and silymarian, was so effective, local hospitals used the same to open so-called ‘liver clinics’ at great profit! Glutamine also serves as the main source of energy for the mucosal cells of the small intestine! Therefore, glutamine also helps greatly in the digestion of food. Without it, your small intestines would be in real trouble! The cells of the GI tract use glutamine to create the energy they need to function, to protect the body from foreign invaders, and to modulate the size of the pores or “leakiness” of the intestines thereby allowing food into the bloodstream. In addition to supplying energy for intestinal epithelial cells, glutamine stimulates the proliferation of intestinal epithelial cells [1] . Studies demonstrated that glutamine decreased bacterial translocation and stimulated IgA mucosal secretion [2,3] , ; and initiates anti-inflammatory effects [4] . You’ll note the connection between immunity and GI tract. Around the GI tract are wandering immune cells always patrolling for foreign invaders in a potentially hostile environment. In fact, 70% of your immunity surrounds the GI tract – Thus, any GI tract troubles eventually become immune system problems! And immune system problems can destroy the body! Glutamine protects the body from assaults in the GI tract. Assaults to the immune system through the GI tract include: GMO foods (GMO foods were manufactured by adding the foreign DNA of bacteria, viruses and fungus), and pathogens (viruses, bacteria, fungus, protozoa like cryptosporidium, and parasites)! If the Glutamine storage in your GI tract gets low, you won’t be very well protected from pathogens, you will have difficulty digesting nutrients, and can develop ‘leaky gut syndrome’ (where things leak into the blood stream that do not belong there – All of which gives rise to increased immune system trauma). Collectively these events conspire to ramp up autoimmune disorders! In other words, without enough Glutamine, your body can’t prevent food allergies or fight illness! One of the most serious side-effects of HIV infection is diarrhea. We found that Glutamine supplementation is the most effective treatment for diarrhea on the planet – AND WITHOUT ANY SIDE EFFECTS associated with medications like Imodium! Immune cells also participate in the production of hormones and even participate in neurotransmitter communication with the brain. A challenged immune system causes diabetes, (types 1 and 2), chronic pain, anxiety and depression. Poor immunity leads to hormonal imbalance and mental disease. Glutamine not only makes up a significant part of immunity, it is a major excitatory neurotransmitter of the brain! [1] Bamba T, Kanauchi O, Andoh A, Fujiyama Y. A new prebiotic from germinated barley for nutraceutical treatment of ulcerative colitis. J Gastroenterol Hepatol. 2002;17(8):818–824. [2] Kudsk KA, Wu Y, Fukatsu K, et al. Glutamine-enriched total parenteral nutrition maintains intestinal interleukin-4 and mucosal immunoglobulin A levels. JPEN J Parenter Enteral Nutr. 2000;24(5):270–274. [3] Chen K, Okuma T, Okamura K, Torigoe Y, Miyauchi Y. Glutamine-supplemented parenteral nutrition improves gut mucosa integrity and function in endotoxemic rats. JPEN J Parenter Enteral Nutr. 1994;18(2):167–171. [4] Singleton KD, Beckey VE, Wischmeyer PE. Glutamine prevents activation of NF-κB and stress kinase pathways, attenuate inflammatory cytokine release, and prevents acuter respiratory distress syndrome (ARDS) following sepsis. Shock. 2005;24(6):583–589.