Bests & Worsts Reviews from Amazon

update: Found a pubmed (#2409763) titled "Histamine secretion induced by NAC" so that must explain my reaction to it. I started taking NAC again this year and worked up to two pills a day gradually on an empty stomach (1 AM, 1 PM) only to experience worsening breathing again like last time. I have been trying out some other amino acids including histidine, which I just started. Histidine is supposed to be a precursor to histamine, but antagonistic to it at the same time. So if you are lacking histidine, you will have too much histamine and vice versa. Also, I have read that people who suffer from asthma/eczema problems could be genetically deficient in filaggrin FLG gene which has shown to be helped with histidine supplementation. So I am trying to fix my histamine problem first with histidine before again continuing with the NAC. I am also taking glycine and glutamine to help boost whatever glutathione production that I can though lacking the cysteine supplementation for now. original review: I think this is an excellent product but heads up - be careful using NAC if your methylation pathways are not working properly, if you have MTHFR genes, things like that. I found out the hard way. Taking one a day or one every few days, worked pretty good for me. If my sinuses were stuffed up, taking one of these almost immediately opened them up and mucous would start draining all over the place and it's lovely to be able to breathe through your nose. I decided to take 3 one day to try and boost my glutathione levels. I took one before breakfast and then two before lunch, and then had a terrible reaction: almost a full-blown asthma attack and two cold sores showed up on my lips like that (snaps fingers). It was pretty shocking and my rescue inhalers were doing nothing to calm it down and I even contemplated going to the hospital. It went on for at least half the day. I looked it up and found a few articles discussing some patients having severe anaphylactic reactions to NAC at hospitals and being treated extremely successfully with antihistamines. So I popped a cytirizine, and thankfully it worked like magic within half an hour all the badness went away, even my cold sores disappeared that night (which never happens, usually they explode into works of art on my face). Then I dug into more research and found out that bad reactions to NAC are usually indicative of problems with your methylation pathways. Supplementing with folate/folinic acid and betaine TMG seems to be the way to fix that, so that's what I'm trying now. I might try and reincorporate the NAC down the road but I wanted to tell other people about my experience just in case.