Bests & Worsts Reviews from Amazon

I am compound heterozygous MTHFR A1298C + C677T. Have suffered severe chemical depression since I was in high school. After receiving these test results my psychiatrist put me on Deplin, and when those ran out I opted to Amazon for l-methylfolate. I have switched around different brands, and after much research and through experimentation I noticed that when I added a Betaine supplement my energy levels were instantly increased, that day. The folate + betaine relationship is explained in a few papers but the gist is that betaine provides the right pH in stomach for the vitamin to be properly absorbed. Folate is a water-soluble and tricky vitamin. I have just started taking this at night time now, because I simply no longer eat enough during day to want to waste taking a pill. This being my first time with this brand, I did not notice a major difference, but that is because I've already been taking l-methylfolate. It seems to be keeping up and doing its job. This stuff will make you pee neon yellow after; I didn't notice that in previous brands. It doesn't bother me but worth mentioning . I purchased this product specifically because it also has B12, which is needed in the methylation cycle. B9 and B12 are needed together in adequate amounts. I also like that there is some niacin in here as I wanted to start that. I am definitely going to keep purchasing this product for the price point and nutritional value.