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So first things first. Sam-E is not for everyone. If it doesn't work for you, it doesn't mean the product is bad; it likely means what you've got going on doesn't need this ingredient to get better. Working with a doctor, using symptoms and saliva tests for neurotransmitters, it was apparent that what I had going on had to do with a certain conversion not happening. Sam-E is the ingredient that promotes that process and it worked better than expected. It's not the cheapest solution for better methylation but it's the easiest to acquire. Needs B vitamins to work well.