Bests & Worsts Reviews from Amazon

I stumbled upon this wonderful product and so glad I did! I have the C677T MTHFR mutation, as well as a COMT mutation. MTHFR converts B-12 and Folate (and other vitamins) to the active/methylated forms that can be used by the body and cross the blood brain barrier. Because I have both MTHFR and COMT mutations, it is best that I take B12 in the form of Adenosylcobalamin (along with Methylcobalamin), which this product has. I was taking Thorne Methyl Guard Plus, which has a higher potency of Methylfolate and B12 Methylcobalamin (and no Adenosylcobalamin), but noticed it made me a little irritable, edgy. So after watching a presentation by Dr. Ben Lynch (MTHFR.net) – a leader in MTHFR research - I learned that B12 Adenosylcobalamin can help reduce irritability, anger, etc. that those with COMT mutations can have when they take too much methylfolate. This supplement has helped “take the edge off” (pun intended).  This particular supplement formulation seems to work for me, my son and my father. I have noticed increased energy and mood stability and less irritability in all of us. And, as for my 90-year-old father, he was on antidepressants for 10 years (as well as on and off of them for the prior 55 years). 2014 blood work showed B12 deficiency, so he started B12 (cyanocobalamin) shots, but saw no improvement, and his antidepressants were gradually increased. In October 2015, his blood work showed he was in range for B12 and folate, but his homocysteine level was high. Because of the research I had done on MTHFR, I knew right away that my dad had an MTHFR mutation, because (1) when blood homocysteine is elevated while B12 and Folate are in the normal range, that indicates the body is not properly converting folic acid to methylated folate and B12 (cyanocobalamin-synthetic form) to methylated B12 (active forms used by the body); (2) I had to get my MTHFR mutation from a parent. The form of B12 in the shots my dad was taking monthly is cyanocobalamin, which is synthetic and cheap and requires properly working MTHFR for conversion. So keep in mind that B12 and folate levels in blood work alone is not an accurate indicator of whether or not the body is actually converting to active forms required for the body to utilize. The addition of a homocysteine test is more revealing. Since my dad started taking Thorne B Complex #12, he is completely off of antidepressants and doing well! His doctors are intrigued and impressed. I gave them the information and hope they will use it to help other patients. Every person is different. It is best to start with lower potency supplements and work your way up to prevent reactions (in my case, reaction to too much methylfolate). Dr. Ben Lynch has two MTHFR mutations himself, so he has a personal interest in this field. MTHFR.net is a FABULOUS resource for those struggling with MTHFR mutations, or those who want to find out if they have such mutations. It is now believed that at least 50% of the population has some MTHFR variant (SNPs), which can cause a host of problems, including fibromyalgia, miscarriages, severe depression, autism and much more. While there is typically not one “smoking gun” that causes all our ailments, I believe MTHFR is a good place to start. MTHFR.net can tell you which tests to have and where to get them. I hope this helps someone!