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If you don't understand MTHFR, you should look it up. There is a great article called, 'Holy MTHFR' that gives a great explanation. It's a genetic defect that predisposes someone to depression, anxiety, stress, fear, etc. I've done counseling for two decades and there are times that nothing helps someone who is depressed. This stuff is amazing. Has literally changed hundreds of people's lives in my sphere of influence. It's also amazing for people with Borderline Personality Disorder type of thinking (it's all about me and I'll blame you for all of my bad decisions, kind of person). My husband was (and I say WAS) one of those (like a 2 on the 10-point richter scale). We tried everything.. like the "Stop Walking On Eggshells" books or "Out Of Control" by Melanie Sheets. Nothing really worked super well. MTHFR is diagnosed through a simple blood test. Many naturopaths will run it for you. When we both got tested for MTHFR, he had an A and a C marker. He started taking this and he was a different man. Things that would set him off in a tizzy that would last for weeks, now were resolved in minutes...and he'd laugh about it. After two months the "Mr. Magoo" type of crabbiness started returning. I didn't care about the negative fallout I'd get if I asked the question, "Are you still taking the Methylfolate?" He said he'd run out of it a week earlier. Holy Lord, I've ordered enough until Jesus returns. It's truly a miracle, this stuff.