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As of the writing of this review I have taken Lions Mane for one week. The changes I have noticed in myself were subtle at first, but became more profound as each day went by. I am taking the capsules, and I take 1 or 2 per day. I am a 58 year old night shift nurse battling depression, fatigue, and brain fog. So here are just a few of the changes in me: I am more keenly aware of my surroundings. The pain of clinical depression seems to have dissipated. I positively have more energy which helps tremendously at the end of my shift. And I am much more patient with doctors, ARNP’s and pharmacists even when by their action or inaction have placed my patients in jeopardy. Maintaining civility and professionalism is important when advocating for the needs of my patients. Depressing thoughts have strangely disappeared. My patients have noticed that I am more upbeat and cheerful. I have also noticed that I am more engaged with my wife in conversation and physical affection. I am more in tune with her wants and needs. And I am genuinely interested in hearing about her day. Am I a brand new man? No, but I am functioning much better, and I am very grateful for Lions Mane mushrooms. In a simple sentence: I feel like I am waking up.