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I am almost very hesitant to write this review, because I'm afraid I'll jinx myself, but I simply have to report the truth. I have read all of the glowing reports about how DMSO just eliminates the pain, and that, of course, is what I have been hoping against hope to find, somehow, to solve my lower back pain, which has plagued me for many years. You wonder just what you can do to alleviate such terrible pain, and at times it really is bad, but at other times it is fairly tolerable. Well, I got the roll-on, and after I tried it and realized, rather foolishly, that I had not removed the plastic cap covering the ball, and wondered why the ball seemed to roll so stiffly, and produced seemingly little liquid, I put on my glasses and could see that there was a protective cover over the ball, so I scraped it off with my fingernail, and the ball rolled easily, and liquid came forth, and I felt rather stupid. Anyway, I had bought the book about DMSO, and with all of the hullabaloo about the problems getting it approved for human use, and the fact that it has been marketed as a solvent, you are a little wary. Especially when some people talk about a garlic smell, and/or garlic breath, and/or redness on the skin, etc. etc. Well, I rolled it on, and it does have a distinctive smell, but nothing unpleasant, and not even very strong. But no redness of skin, at all, or pain upon application, of any kind. And no garlic breath. Now, I have, as I said, had this lower back pain for quite some time, and have gone through many different attempts to fix it, including various pills, and creams, and sprays, etc. etc., but nothing has actually seemed to make much difference, if any at all. To my utter amazement, and obviously, also my utter delight, I have noticed these last several days that I simply don't have any back pain. And I haven't used the roll-on, except for a couple of times in the last several days, after the first couple of days after I got it, of course I put it on. Even in the morning - when it is (or has been) at its worst, I did wake up this morning with lower back pain, but nothing as bad as it has been in the past, and even that seemed to fade after I had been up for a couple of hours. Maybe - just maybe - this is finally the "magic bullet" that I have been seeking; I don't feel like a spring chicken, but then those days are probably long gone anyway, but at least I don't have that awful, throbbing, terrible lower back pain that really makes your life miserable. As I sit here writing this, I don't feel anything in my back, AT ALL, and that is wonderful!