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Not all liposome formulations are created equal
I much prefer the Lypo–Spheric brand Vitamin C, however, the NutriFlair C is about half as expensive and has far more doses (I believed) so I thought I’d try it. I noticed this brand is Ascorbyl Palmitate. THEN, I came across this interesting article on C Easter:
https://coremedscience.com/blogs/wellness/how-to-pick-the-best-liposomal-vitamin-c
“The "Fat Soluble" Vitamin C Ester Myth
A perfect example of a product taking advantage of the "liposomal" term is a type of vitamin C a vitamin C ester. Usually labeled as "fat soluble" vitamin C, esters like Ascorbyl Palmitate are marketed as a “liposomal” but will never result in forming an actual "liposome".
Here are some important facts about "fat soluble" Ascorbyl Palmitate:
Ascorbyl palmitate is not found in nature. It is SYNTHETIC, made by combining palmitate (an ester, fat) with vitamin C (Ascorbic Acid).
Ascorbyl palmitate is used as a "FOOD PRESERVATIVE" to extend the shelf life of certain foods, medications, and cosmetics.
Ascorbyl Palmitate is also known as "Cetyl Ascorbate"....(two different names for the same compound)
Ascorbyl Palmitate is ONLY 42.5% VITAMIN C
Products that claim "1600 mg Liposomal Vitamin C" using Ascorbyl Palmitate ONLY PROVIDE 680 mg of actual vitamin C (Ascorbic Acid)
This last point is very important. Because Ascorbyl Palmitate is made by combining vitamin C (Ascorbic Acid) to Palmitate (a fat), less than half of it is true vitamin C ! (source 20, source 21).
Ascorbyl Oleate is another vitamin C ester very similar to the Ascorbyl Palmitate compound, binding Oleate (another fat) to ascorbic acid.
Ester forms of vitamin C, like Ascorbyl Palmitate, are easily digested after oral ingestion by enzymes in the small intestine which cleave the bond immediately releasing just plain vitamin C (ascorbic acid molecule) and the ester, in this case palmitate, before any absorption can take place.
When this digestion happens, plain vitamin C is released from the ester and no improved absorption occurs when compared to a standard vitamin C supplement. ( source 15, source 16 ). The bioavailability of fat soluble vitamin C esters is essentially identical to plain vitamin C (Ascorbic Acid) alone. ( Source 18 )
The esters used may even have a negative impact, depending on the ingredient itself.
Unlike natural vitamin C (Ascorbic Acid), Ascorbyl Palmitate may actually be toxic to skin cells damaged by UV exposure according to one study. ( Source 17 )
The bottom line is this: These “Fat Soluble” forms of vitamin C (ascorbyl palmitate, alscorbyl oleate, cetyl ascorbate), are rapidly digested before any absorption takes place, releasing plain vitamin C in your small intestine. Adding to the deception, "Fat Soluble" Vitamin C CONTAINS LESS THAN HALF actual vitamin C (Ascorbic Acid)!
Unfortunately few people know this, results in unassuming customers paying top dollar for a product that is not much different than a standard vitamin C capsule or powder but has the term "liposomal" attached to it.”
So... I’m back to buying the Lypo–Spheric brand Vitamin C. I’ve found that five or six 1,0000 mg packets will stop a cold in it’s tracks if taken at first signs of illness.
July 2020 · Health and Household · verified purchase