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The reason that people have all kinds of issues with this b vitamin is because it has b12 in the form of cyanocobolamin. As the name implies, it has cyanide, which is s toxic substance. Some people may not show a reaction, but those that have a reaction feel very sick. To avoid this problem, whenever you take a supplement that has vit b 12, make sure that the b12 is in the form of methylcobolamin